Haemodynamic studies in high altitude pulmonary oedema.

Polymorphisms of human vascular endothelial growth factor gene in high-altitude pulmonary oedema susceptible subjects.

BACKGROUND AND OBJECTIVE Based on the reported biological properties and function of vascular endothelial growth factor (VEGF) in hypoxic conditions, many investigations have studied the hypothesis that VEGF has an important role in the pathogenesis of high altitude sicknesses, including high-altitude pulmonary oedema (HAPE). Unfortunately, the results are inconsistent. Therefore, the associati...

Unravelling the Pathogenesis of Severe COVID-19 Pneumonia: Are There Possible Insights From High Altitude?

Ultrastructure of high altitude pulmonary oedema.

Heath, D., Moosavi, H., and Smith, P. (1973). Thorax, 28, 694-700. Ultrastructure of high altitude pulmonary oedema. When rats are exposed for 12 hours to simulated high altitude corresponding to the summit of Mount Everest, they develop ultrastructural changes in the lungs. These consist of the formation and protrusion of multiple endothelial vesicles into the pulmonary capillaries. It seems l...

High altitude-induced pulmonary oedema.

Almost one mountain trekker or climber out of two develops several symptoms of high altitude illness after a rapid ascent (> 300 m/day) to an altitude above 4000 m. Individual susceptibility is the most important determinant for the occurrence of high altitude pulmonary oedema (HAPE). Symptoms associated with HAPE are incapacitating fatigue, chest tightness, dyspnoea at the slightest effort, or...

Impedance cardiography as a tool for haemodynamic monitoring at high altitude: a preliminary study.

BACKGROUND Altitude illness is a relevant threat to the life and health of participants in mountaineering expeditions. AIM To determine if impedance cardiography (ICG) can be used in noninvasive monitoring of haemodynamic disturbances at high altitude. METHODS The study was performed in a group of 13 participants of two mountaineering expeditions in the Himalayas. The ICG examination was pe...